* 4 or more goals scored in the match
| Date | Venue | Player | Opposition | Result | Competition | Goals |
|---|---|---|---|---|---|---|
| 15 Oct 1892 | A | John Miller | Nantwich | 4 - 0 | FA Cup 1st Qualifier | 3 |
| 22 Oct 1892 | A | John Miller | Higher Walton | 5 - 0 | Lancashire League | 3 |
| 29 Oct 1892 | H | Tom Wyllie | Newtown | 9 - 0 | FA Cup 2nd Qualifier | 3 |
| 03 Dec 1892 | H | John Miller | Fleetwood Rangers | 7 - 0 | Lancashire League | 5* |
| 07 Oct 1893 | H | Jimmy Stott | Middlesbrough Ironopolis | 6 - 0 | 2nd Division | 3 |
| 09 Dec 1893 | H | Malcolm McVean | Walsall | 3 - 0 | 2nd Division | 3 |
| 14 Sep 1895 | H | Jimmy Ross | Newcastle United | 5 - 1 | 2nd Division | 3 |
| 28 Sep 1895 | H | George Allan | Port Vale | 5 - 1 | 2nd Division | 4* |
| 21 Oct 1895 | A | Frank Becton | Port Vale | 4 - 5 | 2nd Division | 3 |
| 04 Jan 1896 | A | George Allan | Rotherham Town | 5 - 0 | 2nd Division | 3 |
| 18 Feb 1896 | H | George Allan | Rotherham Town | 10 - 1 | 2nd Division | 4* |
| 18 Feb 1896 | H | Malcolm McVean | Rotherham Town | 10 - 1 | 2nd Division | 3 |
| 29 Feb 1896 | A | Frank Becton | Burton Swifts | 7 - 0 | 2nd Division | 3 |
| 29 Feb 1896 | A | Jimmy Ross | Burton Swifts | 7 - 0 | 2nd Division | 3 |
| 28 Mar 1896 | A | George Allan | Crewe Alexandra | 7 - 0 | 2nd Division | 3 |
| 08 Apr 1899 | H | Johnny Walker | Derby County | 4 - 0 | 1st Division | 3 |
| 23 Dec 1899 | H | Charlie Satterthwaite | Glossop North End | 5 - 2 | 1st Division | 3 |
| 04 Jan 1902 | H | Andy McGuigan | Stoke City | 7 - 0 | 1st Division | 5* |
| 01 Mar 1902 | H | Sam Raybould | Manchester City | 4 - 0 | 1st Division | 3 |
| 01 Nov 1902 | H | Sam Raybould | Middlesbrough | 5 - 0 | 1st Division | 3 |
| 06 Dec 1902 | H | Sam Raybould | Grimsby Town | 9 - 2 | 1st Division | 4* |
| 01 Oct 1904 | H | Bobby Robinson | Leicester City | 4 - 0 | 2nd Division | 4* |
| 04 Mar 1905 | H | Jack Parkinson | Blackpool | 5 - 0 | 2nd Division | 3 |
| 18 Mar 1905 | H | Sam Raybould | Gainsborough Trinity | 6 - 1 | 2nd Division | 3 |
| 08 Apr 1905 | H | Bobby Robinson | Port Vale | 8 - 1 | 2nd Division | 3 |
| 22 Apr 1905 | H | Sam Raybould | Manchester United | 4 - 0 | 2nd Division | 3 |
| 11 Nov 1905 | A | Joe Hewitt | Middlesbrough | 5 - 1 | 1st Division | 3 |
| 10 Mar 1906 | H | Sam Raybould | Southampton | 3 - 0 | FA Cup 4th round | 3 |
| 28 Apr 1906 | N | Joe Hewitt | Corinthians | 5 - 1 | Sheriff of London Charity Shield | 3 |
| 27 Oct 1906 | H | Bobby Robinson | Manchester City | 5 - 4 | 1st Division | 3 |
| 19 Jan 1907 | A | Jack Parkinson | Sunderland | 5 - 5 | 1st Division | 3 |
| 09 Nov 1907 | H | Joe Hewitt | Notts County | 6 - 0 | 1st Division | 3 |
| 15 Feb 1908 | H | Joe Hewitt | Arsenal | 4 - 1 | 1st Division | 3 |
| 25 Mar 1908 | H | Bill McPherson | Manchester United | 7 - 4 | 1st Division | 3 |
| 01 Jan 1909 | A | Joe Hewitt | Sunderland | 4 - 1 | 1st Division | 3 |
| 16 Jan 1909 | H | Ronald Orr | Lincoln City | 5 - 1 | FA Cup 1st round | 3 |
| 18 Sep 1909 | A | Jack Parkinson | Nottingham Forest | 4 - 1 | 1st Division | 3 |
| 01 Jan 1910 | H | Jack Parkinson | Arsenal | 5 - 1 | 1st Division | 3 |
| 08 Jan 1910 | H | Jimmy Stewart | Chelsea | 5 - 1 | 1st Division | 3 |
| 20 Apr 1910 | H | Jack Parkinson | Nottingham Forest | 7 - 3 | 1st Division | 4* |
| 11 Feb 1911 | H | Jack Parkinson | Sheffield Wednesday | 3 - 0 | 1st Division | 3 |
| 01 Feb 1913 | A | Arthur Metcalf | Arsenal | 4 - 1 | FA Cup 2nd round | 3 |
| 19 Apr 1913 | H | Jack Parkinson | Bolton Wanderers | 5 - 0 | 1st Division | 3 |
| 31 Oct 1914 | H | Fred Pagnam | Tottenham Hotspur | 7 - 2 | 1st Division | 4* |
| 13 Feb 1915 | H | Fred Pagnam | Chelsea | 3 - 3 | 1st Division | 3 |
| 03 Apr 1920 | H | Dick Forshaw | Derby County | 3 - 0 | 1st Division | 3 |
| 25 Sep 1920 | H | Dick Johnson | Preston North End | 6 - 0 | 1st Division | 3 |
| 19 Nov 1921 | H | Danny Shone | Middlesbrough | 4 - 0 | 1st Division | 3 |
| 25 Feb 1922 | H | Dick Forshaw | Arsenal | 4 - 0 | 1st Division | 3 |
| 15 Apr 1922 | H | Harry Chambers | Cardiff City | 5 - 1 | 1st Division | 3 |
| 26 Aug 1922 | H | Dick Johnson | Arsenal | 5 - 2 | 1st Division | 3 |
| 16 Sep 1922 | H | Dick Forshaw | Preston North End | 5 - 2 | 1st Division | 3 |
| 07 Oct 1922 | H | Harry Chambers | Everton | 5 - 1 | 1st Division | 3 |
| 17 Feb 1923 | H | Dick Forshaw | Blackburn Rovers | 3 - 0 | 1st Division | 3 |
| 29 Aug 1923 | H | Harry Chambers | Birmingham City | 6 - 2 | 1st Division | 3 |
| 02 Feb 1924 | A | Jimmy Walsh | Bolton Wanderers | 4 - 1 | FA Cup 2nd round | 3 |
| 18 Oct 1924 | H | Dick Forshaw | Sheffield United | 4 - 1 | 1st Division | 4* |
| 19 Sep 1925 | H | Dick Forshaw | Manchester United | 5 - 0 | 1st Division | 3 |
| 26 Sep 1925 | H | Dick Forshaw | Everton | 5 - 1 | 1st Division | 3 |
| 25 Dec 1925 | H | Harry Chambers | Newcastle United | 6 - 3 | 1st Division | 3 |
| 28 Aug 1926 | H | Dick Forshaw | Manchester United | 4 - 2 | 1st Division | 3 |
| 11 Sep 1926 | H | Gordon Hodgson | Sheffield United | 5 - 1 | 1st Division | 3 |
| 12 Jan 1927 | H | Harry Chambers | Bournemouth | 4 - 1 | FA Cup 3rd round replay | 3 |
| 22 Jan 1927 | H | Gordon Hodgson | Derby County | 3 - 2 | 1st Division | 3 |
| 31 Aug 1927 | H | Willie Devlin | Bury | 5 - 1 | 1st Division | 4* |
| 01 Oct 1927 | H | Gordon Hodgson | Portsmouth | 8 - 2 | 1st Division | 3 |
| 01 Oct 1927 | H | Willie Devlin | Portsmouth | 8 - 2 | 1st Division | 4* |
| 12 Nov 1927 | H | Tom Reid | Sheffield Wednesday | 5 - 2 | 1st Division | 3 |
| 27 Oct 1928 | A | Gordon Hodgson | Arsenal | 4 - 4 | 1st Division | 3 |
| 26 Dec 1928 | H | Gordon Hodgson | Burnley | 8 - 0 | 1st Division | 3 |
| 20 Apr 1929 | H | Harry Race | Sunderland | 5 - 2 | 1st Division | 3 |
| 09 Nov 1929 | H | Harry Race | Bolton Wanderers | 3 - 0 | 1st Division | 3 |
| 27 Sep 1930 | H | Gordon Hodgson | Chelsea | 3 - 1 | 1st Division | 3 |
| 25 Oct 1930 | A | Jimmy Smith | Blackpool | 3 - 1 | 1st Division | 3 |
| 29 Nov 1930 | H | Gordon Hodgson | Sheffield United | 6 - 1 | 1st Division | 3 |
| 07 Feb 1931 | H | Dave Wright | Newcastle United | 4 - 2 | 1st Division | 3 |
| 14 Feb 1931 | A | Gordon Hodgson | Sheffield Wednesday | 5 - 3 | 1st Division | 4* |
| 28 Feb 1931 | H | Gordon Hodgson | Blackpool | 5 - 2 | 1st Division | 3 |
| 23 Jan 1932 | A | Harold Barton | Chesterfield | 4 - 2 | FA Cup 4th round | 4* |
| 02 Mar 1932 | H | Gordon Hodgson | West Bromwich Albion | 4 - 1 | 1st Division | 3 |
| 15 Oct 1932 | H | Gordon Hodgson | Portsmouth | 4 - 3 | 1st Division | 3 |
| 19 Nov 1932 | H | Gordon Hodgson | Derby County | 6 - 1 | 1st Division | 3 |
| 11 Feb 1933 | H | Harold Barton | Everton | 7 - 4 | 1st Division | 3 |
| 08 Apr 1933 | H | Gordon Hodgson | Blackpool | 4 - 3 | 1st Division | 3 |
| 03 Mar 1934 | H | Gordon Hodgson | Middlesbrough | 6 - 2 | 1st Division | 3 |
| 17 Mar 1934 | H | Gordon Hodgson | Birmingham City | 4 - 1 | 1st Division | 4* |
| 17 Nov 1934 | H | Gordon Hodgson | Leicester City | 5 - 1 | 1st Division | 3 |
| 02 Feb 1935 | H | Gordon Hodgson | Leeds United | 4 - 2 | 1st Division | 3 |
| 07 Sep 1935 | H | Fred Howe | Everton | 6 - 0 | 1st Division | 4* |
| 14 Sep 1935 | H | Fred Howe | Grimsby Town | 7 - 2 | 1st Division | 3 |
| 21 Nov 1936 | A | Fred Howe | Manchester United | 5 - 2 | 1st Division | 3 |
| 19 Oct 1946 | A | Cyril Done | Huddersfield Town | 4 - 1 | 1st Division | 3 |
| 09 Nov 1946 | H | Jack Balmer | Portsmouth | 3 - 0 | 1st Division | 3 |
| 16 Nov 1946 | A | Jack Balmer | Derby County | 4 - 1 | 1st Division | 4* |
| 23 Nov 1946 | H | Jack Balmer | Arsenal | 4 - 2 | 1st Division | 3 |
| 12 Feb 1947 | H | Cyril Done | Grimsby Town | 5 - 0 | 1st Division | 3 |
| 01 Mar 1947 | H | Albert Stubbins | Birmingham City | 4 - 1 | FA Cup 6th round | 3 |
| 10 May 1947 | A | Albert Stubbins | Charlton Athletic | 3 - 1 | 1st Division | 3 |
| 06 Mar 1948 | H | Albert Stubbins | Huddersfield Town | 4 - 0 | 1st Division | 4* |
| 01 Dec 1951 | A | Billy Liddell | Tottenham Hotspur | 3 - 2 | 1st Division | 3 |
| 19 Sep 1953 | H | Louis Bimpson | Burnley | 4 - 0 | 1st Division | 4* |
| 21 Aug 1954 | H | Tony Rowley | Doncaster Rovers | 3 - 2 | 2nd Division | 3 |
| 15 Sep 1954 | H | John Evans | Bristol Rovers | 5 - 3 | 2nd Division | 5* |
| 18 Sep 1954 | H | Billy Liddell | Fulham | 4 - 1 | 2nd Division | 3 |
| 25 Dec 1954 | H | Billy Liddell | Ipswich Town | 6 - 2 | 2nd Division | 4* |
| 12 Mar 1955 | A | John Evans | Bury | 4 - 3 | 2nd Division | 4* |
| 17 Dec 1955 | H | Billy Liddell | Nottingham Forest | 5 - 2 | 2nd Division | 3 |
| 14 Apr 1956 | H | Tony Rowley | Port Vale | 4 - 1 | 2nd Division | 3 |
| 03 Nov 1956 | H | Johnny Wheeler | Port Vale | 4 - 1 | 2nd Division | 3 |
| 15 Dec 1956 | A | Alan Arnell | Huddersfield Town | 3 - 0 | 2nd Division | 3 |
| 22 Feb 1958 | A | Billy Liddell | Blackburn Rovers | 3 - 3 | 2nd Division | 3 |
| 26 Nov 1960 | H | Jimmy Harrower | Sheffield United | 4 - 2 | 2nd Division | 3 |
| 11 Feb 1961 | H | Dave Hickson | Leyton Orient | 5 - 0 | 2nd Division | 3 |
| 04 Apr 1961 | A | Kevin Lewis | Bristol Rovers | 3 - 4 | 2nd Division | 3 |
| 26 Aug 1961 | H | Roger Hunt | Leeds United | 5 - 0 | 2nd Division | 3 |
| 14 Oct 1961 | H | Roger Hunt | Walsall | 6 - 1 | 2nd Division | 3 |
| 25 Nov 1961 | H | Roger Hunt | Swansea City | 5 - 0 | 2nd Division | 3 |
| 10 Feb 1962 | A | Roger Hunt | Bury | 3 - 0 | 2nd Division | 3 |
| 24 Feb 1962 | H | Roger Hunt | Middlesbrough | 5 - 1 | 2nd Division | 3 |
| 28 Mar 1962 | H | Ian St John | Rotherham United | 4 - 1 | 2nd Division | 3 |
| 17 Nov 1962 | H | Roger Hunt | Leyton Orient | 5 - 0 | 1st Division | 3 |
| 26 Dec 1963 | H | Roger Hunt | Stoke City | 6 - 1 | 1st Division | 4* |
| 04 Jan 1964 | H | Alf Arrowsmith | Derby County | 5 - 0 | FA Cup 3rd round | 4* |
| 01 Feb 1964 | H | Ian St John | Sheffield United | 6 - 1 | 1st Division | 3 |
| 27 Mar 1964 | A | Roger Hunt | Tottenham Hotspur | 3 - 1 | 1st Division | 3 |
| 26 Sep 1964 | H | Bobby Graham | Aston Villa | 5 - 1 | 1st Division | 3 |
| 05 Dec 1964 | A | Roger Hunt | Burnley | 5 - 1 | 1st Division | 3 |
| 06 Sep 1965 | A | Roger Hunt | West Ham United | 5 - 1 | 1st Division | 3 |
| 12 Feb 1966 | H | Roger Hunt | Sunderland | 4 - 0 | 1st Division | 3 |
| 26 Aug 1967 | H | Tony Hateley | Newcastle United | 6 - 0 | 1st Division | 3 |
| 06 Jan 1968 | H | Roger Hunt | West Bromwich Albion | 4 - 1 | 1st Division | 3 |
| 19 Feb 1968 | H | Tony Hateley | Walsall | 5 - 2 | FA Cup 4th round replay | 4* |
| 11 May 1968 | H | Tony Hateley | Nottingham Forest | 6 - 1 | 1st Division | 3 |
| 10 Mar 1971 | H | Alun Evans | Bayern Munich | 3 - 0 | European Fairs Cup 4th round 1st leg | 3 |
| 11 Dec 1971 | H | Jack Whitham | Derby County | 3 - 2 | 1st Division | 3 |
| 17 Nov 1973 | H | Kevin Keegan | Ipswich Town | 4 - 2 | 1st Division | 3 |
| 04 Dec 1973 | H | Ian Callaghan | Hull City | 3 - 1 | League Cup 4th round replay | 3 |
| 07 Sep 1974 | H | Phil Boersma | Tottenham Hotspur | 5 - 2 | 1st Division | 3 |
| 30 Sep 1975 | H | John Toshack | Hibernian | 3 - 1 | UEFA Cup 1st round 2nd leg | 3 |
| 11 Oct 1975 | H | John Toshack | Birmingham City | 3 - 1 | 1st Division | 3 |
| 10 Dec 1975 | H | Jimmy Case | Slask Wroclaw | 3 - 0 | UEFA Cup 3rd round 2nd leg | 3 |
| 31 Jan 1976 | A | John Toshack | West Ham United | 4 - 0 | 1st Division | 3 |
| 06 Dec 1977 | H | Terry McDermott | Hamburg SV | 6 - 0 | European Super Cup 2nd leg | 3 |
| 17 Jan 1978 | A | Kenny Dalglish | Wrexham | 3 - 1 | League Cup 5th round | 3 |
| 01 May 1978 | H | Kenny Dalglish | Manchester City | 4 - 0 | 1st Division | 3 |
| 30 Sep 1978 | H | Jimmy Case | Bolton Wanderers | 3 - 0 | 1st Division | 3 |
| 05 Jan 1980 | H | David Johnson | Grimsby Town | 5 - 0 | FA Cup 3rd round | 3 |
| 09 Feb 1980 | A | David Fairclough | Norwich City | 5 - 3 | 1st Division | 3 |
| 01 Oct 1980 | H | Graeme Souness | Oulu Palloseura | 10 - 1 | European Cup 1st round 2nd leg | 3 |
| 01 Oct 1980 | H | Terry McDermott | Oulu Palloseura | 10 - 1 | European Cup 1st round 2nd leg | 3 |
| 04 Mar 1981 | H | Graeme Souness | CSKA Sofia | 5 - 1 | European Cup 3rd round 1st leg | 3 |
| 26 Jan 1982 | A | Ian Rush | Notts County | 4 - 0 | 1st Division | 3 |
| 06 Nov 1982 | A | Ian Rush | Everton | 5 - 0 | 1st Division | 4* |
| 13 Nov 1982 | H | Ian Rush | Coventry City | 4 - 0 | 1st Division | 3 |
| 27 Dec 1982 | H | Kenny Dalglish | Manchester City | 5 - 2 | 1st Division | 3 |
| 01 Jan 1983 | H | Ian Rush | Notts County | 5 - 1 | 1st Division | 3 |
| 15 Oct 1983 | A | Michael Robinson | West Ham United | 3 - 1 | 1st Division | 3 |
| 29 Oct 1983 | H | Ian Rush | Luton Town | 6 - 0 | 1st Division | 5* |
| 20 Jan 1984 | A | Ian Rush | Aston Villa | 3 - 1 | 1st Division | 3 |
| 07 May 1984 | H | Ian Rush | Coventry City | 5 - 0 | 1st Division | 4* |
| 03 Oct 1984 | H | John Wark | Lech Poznan | 4 - 0 | European Cup 1st round 2nd leg | 3 |
| 24 Oct 1984 | H | Ian Rush | Benfica | 3 - 1 | European Cup 2nd round 1st leg | 3 |
| 20 Feb 1985 | H | John Wark | York City | 7 - 0 | FA Cup 5th round replay | 3 |
| 10 Mar 1985 | A | Ian Rush | Barnsley | 4 - 0 | FA Cup 6th round | 3 |
| 23 Mar 1985 | A | John Wark | West Bromwich Albion | 5 - 0 | 1st Division | 3 |
| 29 Oct 1985 | H | Paul Walsh | Brighton & Hove Albion | 4 - 0 | League Cup 3rd round | 3 |
| 12 Apr 1986 | H | Ronnie Whelan | Coventry City | 5 - 0 | 1st Division | 3 |
| 26 Apr 1986 | H | Gary Gillespie | Birmingham City | 5 - 0 | 1st Division | 3 |
| 23 Sep 1986 | H | Steve McMahon | Fulham | 10 - 0 | League Cup 2nd round 1st leg | 4* |
| 30 Sep 1986 | A | Ian Rush | Everton | 4 - 1 | Screen Sport Super Cup Final 2nd leg | 3 |
| 29 Oct 1986 | H | Steve McMahon | Leicester City | 4 - 1 | League Cup 3rd round | 3 |
| 01 Nov 1986 | H | Paul Walsh | Norwich City | 6 - 2 | 1st Division | 3 |
| 26 Nov 1986 | H | Jan Mølby | Coventry City | 3 - 1 | League Cup 4th round replay | 3 |
| 14 Feb 1987 | H | Ian Rush | Leicester City | 4 - 3 | 1st Division | 3 |
| 20 Sep 1987 | A | Steve Nicol | Newcastle United | 4 - 1 | 1st Division | 3 |
| 29 Sep 1987 | H | John Aldridge | Derby County | 4 - 0 | 1st Division | 3 |
| 27 Aug 1988 | A | John Aldridge | Charlton Athletic | 3 - 0 | 1st Division | 3 |
| 14 Mar 1989 | H | John Aldridge | Luton Town | 5 - 0 | 1st Division | 3 |
| 04 Oct 1989 | A | Steve Staunton | Wigan Athletic | 3 - 0 | League Cup 2nd round 2nd leg | 3 |
| 09 Jan 1990 | H | Ian Rush | Swansea City | 8 - 0 | FA Cup 3rd round replay | 3 |
| 11 Apr 1990 | A | Ronny Rosenthal | Charlton Athletic | 4 - 0 | 1st Division | 3 |
| 05 May 1990 | A | John Barnes | Coventry City | 6 - 1 | 1st Division | 3 |
| 16 Sep 1990 | H | Peter Beardsley | Manchester United | 4 - 0 | 1st Division | 3 |
| 09 Oct 1990 | A | Ian Rush | Crewe Alexandra | 4 - 1 | League Cup 2nd round 2nd leg | 3 |
| 18 Sep 1991 | H | Dean Saunders | Kuusysi Lahti | 6 - 1 | UEFA Cup 1st round 1st leg | 4* |
| 11 Dec 1991 | H | Dean Saunders | Swarovski Tirol | 4 - 0 | UEFA Cup 3rd round 2nd leg | 3 |
| 06 Jan 1992 | A | John Barnes | Crewe Alexandra | 4 - 0 | FA Cup 3rd round | 3 |
| 16 Sep 1992 | H | Ian Rush | Apollon Limassol | 6 - 1 | European Cup Winners' Cup 1st round 1st leg | 4* |
| 17 Apr 1993 | H | Mark Walters | Coventry City | 4 - 0 | Premier League | 3 |
| 05 Oct 1993 | H | Robbie Fowler | Fulham | 5 - 0 | League Cup 2nd round 2nd leg | 5* |
| 27 Oct 1993 | H | Ian Rush | Ipswich Town | 3 - 2 | League Cup 3rd round | 3 |
| 30 Oct 1993 | H | Robbie Fowler | Southampton | 4 - 2 | Premier League | 3 |
| 28 Aug 1994 | H | Robbie Fowler | Arsenal | 3 - 0 | Premier League | 3 |
| 30 Nov 1994 | A | Ian Rush | Blackburn Rovers | 3 - 1 | League Cup 4th round | 3 |
| 23 Sep 1995 | H | Robbie Fowler | Bolton Wanderers | 5 - 2 | Premier League | 4* |
| 23 Dec 1995 | H | Robbie Fowler | Arsenal | 3 - 1 | Premier League | 3 |
| 06 Jan 1996 | H | Stan Collymore | Rochdale | 7 - 0 | FA Cup 3rd round | 3 |
| 14 Dec 1996 | H | Robbie Fowler | Middlesbrough | 5 - 1 | Premier League | 4* |
| 05 Oct 1997 | H | Patrik Berger | Chelsea | 4 - 2 | Premier League | 3 |
| 18 Nov 1997 | H | Michael Owen | Grimsby Town | 3 - 0 | League Cup 4th round | 3 |
| 14 Feb 1998 | A | Michael Owen | Sheffield Wednesday | 3 - 3 | Premier League | 3 |
| 30 Aug 1998 | A | Michael Owen | Newcastle United | 4 - 1 | Premier League | 3 |
| 24 Oct 1998 | H | Michael Owen | Nottingham Forest | 5 - 1 | Premier League | 4* |
| 21 Nov 1998 | A | Robbie Fowler | Aston Villa | 4 - 2 | Premier League | 3 |
| 16 Jan 1999 | H | Robbie Fowler | Southampton | 7 - 1 | Premier League | 3 |
| 06 Sep 2000 | H | Michael Owen | Aston Villa | 3 - 1 | Premier League | 3 |
| 15 Oct 2000 | A | Emile Heskey | Derby County | 4 - 0 | Premier League | 3 |
| 29 Nov 2000 | A | Robbie Fowler | Stoke City | 8 - 0 | League Cup 4th round | 3 |
| 05 May 2001 | H | Michael Owen | Newcastle United | 3 - 0 | Premier League | 3 |
| 08 Aug 2001 | A | Michael Owen | Haka | 5 - 0 | Champions League Qualifier 1st leg | 3 |
| 20 Oct 2001 | A | Robbie Fowler | Leicester City | 4 - 1 | Premier League | 3 |
| 28 Sep 2002 | A | Michael Owen | Manchester City | 3 - 0 | Premier League | 3 |
| 22 Oct 2002 | A | Michael Owen | Spartak Moscow | 3 - 1 | Champions League First Group Phase | 3 |
| 26 Apr 2003 | A | Michael Owen | West Bromwich Albion | 6 - 0 | Premier League | 4* |
| 13 Nov 2004 | H | Milan Baros | Crystal Palace | 3 - 2 | Premier League | 3 |
| 13 Jul 2005 | H | Steven Gerrard | Total Network Solutions | 3 - 0 | Champions League 1st Qualifying round 1st leg | 3 |
| 31 Mar 2007 | H | Peter Crouch | Arsenal | 4 - 1 | Premier League | 3 |
| 25 Sep 2007 | A | Fernando Torres | Reading | 4 - 2 | League Cup 3rd round | 3 |
| 06 Nov 2007 | H | Yossi Benayoun | Besiktas | 8 - 0 | Champions League First Group Phase | 3 |
| 15 Jan 2008 | H | Steven Gerrard | Luton Town | 5 - 0 | FA Cup 3rd round replay | 3 |
| 26 Jan 2008 | H | Yossi Benayoun | Havant & Waterlooville | 5 - 2 | FA Cup 4th round | 3 |
| 23 Feb 2008 | H | Fernando Torres | Middlesbrough | 3 - 2 | Premier League | 3 |
| 05 Mar 2008 | H | Fernando Torres | West Ham United | 4 - 0 | Premier League | 3 |
| 22 Mar 2009 | H | Steven Gerrard | Aston Villa | 5 - 0 | Premier League | 3 |
| 12 Sep 2009 | H | Yossi Benayoun | Burnley | 4 - 0 | Premier League | 3 |
| 26 Sep 2009 | H | Fernando Torres | Hull City | 6 - 1 | Premier League | 3 |
| 04 Nov 2010 | H | Steven Gerrard | Napoli | 3 - 1 | Europa League Group Stage | 3 |
| 06 Mar 2011 | H | Dirk Kuyt | Manchester United | 3 - 1 | Premier League | 3 |
| 23 Apr 2011 | H | Maxi Rodriguez | Birmingham City | 5 - 0 | Premier League | 3 |
| 09 May 2011 | A | Maxi Rodriguez | Fulham | 5 - 2 | Premier League | 3 |
| 13 Mar 2012 | H | Steven Gerrard | Everton | 3 - 0 | Premier League | 3 |
| 28 Apr 2012 | A | Luis Suarez | Norwich City | 3 - 0 | Premier League | 3 |
| 29 Sep 2012 | A | Luis Suarez | Norwich City | 5 - 2 | Premier League | 3 |
| 02 Mar 2013 | A | Luis Suarez | Wigan Athletic | 4 - 0 | Premier League | 3 |
| 12 May 2013 | A | Daniel Sturridge | Fulham | 3 - 1 | Premier League | 3 |
| 26 Oct 2013 | H | Luis Suarez | West Bromwich Albion | 4 - 1 | Premier League | 3 |
| 04 Dec 2013 | H | Luis Suarez | Norwich City | 5 - 1 | Premier League | 4* |
| 22 Mar 2014 | A | Luis Suarez | Cardiff City | 6 - 3 | Premier League | 3 |
| 02 Dec 2015 | A | Divock Origi | Southampton | 6 - 1 | League Cup 5th round | 3 |
| 06 Dec 2017 | H | Philippe Coutinho | Spartak Moscow | 7 - 0 | Champions League First Group Phase | 3 |
| 14 Feb 2018 | A | Sadio Mané | Porto | 5 - 0 | Champions League 1st knockout r. 1st leg | 3 |
| 17 Mar 2018 | H | Mohamed Salah | Watford | 5 - 0 | Premier League | 4* |
| 08 Dec 2018 | A | Mohamed Salah | Bournemouth | 4 - 0 | Premier League | 3 |
| 29 Dec 2018 | H | Roberto Firmino | Arsenal | 5 - 1 | Premier League | 3 |
| 12 Sep 2020 | H | Mohamed Salah | Leeds United | 4 - 3 | Premier League | 3 |
| 03 Nov 2020 | A | Diogo Jota | Atalanta B.C. | 5 - 0 | Champions League First Group Phase | 3 |
| 16 Oct 2021 | A | Roberto Firmino | Watford | 5 - 0 | Premier League | 3 |
| 24 Oct 2021 | A | Mohamed Salah | Manchester United | 5 - 0 | Premier League | 3 |
| 12 Oct 2022 | A | Mohamed Salah | Rangers | 7 - 1 | Champions League First Group Phase | 3 |
| 05 Nov 2024 | H | Luis Diaz | Bayer Leverkusen | 4 - 0 | Champions League - League Phase | 3 |