| # | Date | Opponent | Result | Stadium | Competition |
|---|---|---|---|---|---|
| 17 Sep 1974 | Strømsgodset | 11-0 | Anfield | ECW Cup 1st round 1L | |
| 16 Sep 1969 | Dundalk | 10-0 | Anfield | EFC 1st round 1st leg | |
| 23 Sep 1986 | Fulham | 10-0 | Anfield | League Cup 2nd round 1L | |
| 01 Oct 1980 | Oulu Palloseura | 10-1 | Anfield | European Cup 1st R 2nd L | |
| 18 Feb 1896 | Rotherham Town | 10-1 | Anfield | 2nd Division | |
| 29 Oct 1892 | Newtown | 9-0 | Anfield | FA Cup 2nd Qualifier | |
| 27 Aug 2022 | Bournemouth | 9-0 | Anfield | Premier League | |
| 12 Sep 1989 | Crystal Palace | 9-0 | Anfield | 1st Division | |
| 09 Jan 1990 | Swansea City | 8-0 | Anfield | FA Cup 3rd round replay | |
| 07 Nov 1967 | TSV Munich | 8-0 | Anfield | EFC 2nd round 1st leg | |
| 06 Nov 2007 | Besiktas | 8-0 | Anfield | Champions L. 1st Group Ph. | |
| 03 Sep 1892 | Higher Walton | 8-0 | Anfield | Lancashire League | |
| 26 Dec 1928 | Burnley | 8-0 | Anfield | 1st Division | |
| 06 Dec 1902 | Grimsby Town | 9-2 | Anfield | 1st Division | |
| 08 Apr 1905 | Port Vale | 8-1 | Anfield | 2nd Division | |
| 03 Dec 1892 | Fleetwood Rangers | 7-0 | Anfield | Lancashire League | |
| 04 Jan 1902 | Stoke City | 7-0 | Anfield | 1st Division | |
| 06 Dec 2017 | Spartak Moscow | 7-0 | Anfield | Champions L. 1st Group Ph. | |
| 05 Mar 2023 | Manchester United | 7-0 | Anfield | Premier League | |
| 30 Sep 1981 | Oulu Palloseura | 7-0 | Anfield | European Cup 1st R 2nd L | |
| 02 Sep 1978 | Tottenham Hotspur | 7-0 | Anfield | 1st Division | |
| 20 Feb 1985 | York City | 7-0 | Anfield | FA Cup 5th round replay | |
| 06 Jan 1996 | Rochdale | 7-0 | Anfield | FA Cup 3rd round | |
| 26 Nov 1955 | Fulham | 7-0 | Anfield | 2nd Division | |
| 01 Oct 1927 | Portsmouth | 8-2 | Anfield | 1st Division | |
| 12 Oct 1895 | Manchester United | 7-1 | Anfield | 2nd Division | |
| 12 Sep 1936 | Grimsby Town | 7-1 | Anfield | 1st Division | |
| 16 Jan 1999 | Southampton | 7-1 | Anfield | Premier League | |
| 28 Oct 1995 | Manchester City | 6-0 | Anfield | Premier League | |
| 20 Apr 1935 | Chelsea | 6-0 | Anfield | 1st Division | |
| 07 Sep 1935 | Everton | 6-0 | Anfield | 1st Division | |
| 25 Sep 1920 | Preston North End | 6-0 | Anfield | 1st Division | |
| 22 Mar 1986 | Oxford United | 6-0 | Anfield | 1st Division | |
| 29 Oct 1983 | Luton Town | 6-0 | Anfield | 1st Division | |
| 07 Apr 1984 | West Ham United | 6-0 | Anfield | 1st Division | |
| 06 Dec 1977 | Hamburg SV | 6-0 | Anfield | European Super Cup 2nd leg | |
| 04 Nov 1975 | Real Sociedad | 6-0 | Anfield | UEFA Cup 2nd round 2L | |
| 21 Feb 1979 | Norwich City | 6-0 | Anfield | 1st Division | |
| 26 Aug 1967 | Newcastle United | 6-0 | Anfield | 1st Division | |
| 07 Mar 1964 | Ipswich Town | 6-0 | Anfield | 1st Division | |
| 16 Sep 1963 | Wolves | 6-0 | Anfield | 1st Division | |
| 07 Oct 1893 | Middlesbrough Ironopolis | 6-0 | Anfield | 2nd Division | |
| 09 Nov 1907 | Notts County | 6-0 | Anfield | 1st Division | |
| 01 Sep 2007 | Derby County | 6-0 | Anfield | Premier League | |
| 28 Jan 2026 | Qarabağ FK | 6-0 | Anfield | Champions L - League Ph. | |
| 23 Feb 2022 | Leeds United | 6-0 | Anfield | Premier League | |
| 31 Oct 1914 | Tottenham Hotspur | 7-2 | Anfield | 1st Division | |
| 14 Sep 1935 | Grimsby Town | 7-2 | Anfield | 1st Division | |
| 10 Sep 1930 | Bolton Wanderers | 7-2 | Anfield | 1st Division | |
| 16 Sep 1931 | Middlesbrough | 7-2 | Anfield | 1st Division | |
| 29 Nov 2000 | Stoke City | 8-0 | Britannia St. | League Cup 4th round | |
| 28 Mar 1896 | Crewe Alexandra | 7-0 | Nantwich Road | 2nd Division | |
| 29 Feb 1896 | Burton Swifts | 7-0 | Peel Croft | 2nd Division | |
| 21 Mar 2006 | Birmingham City | 7-0 | St Andrews | FA Cup 6th round | |
| 17 Oct 2017 | NK Maribor | 7-0 | Ljudski vrt | Champions L. 1st Group Ph. | |
| 19 Dec 2020 | Crystal Palace | 7-0 | Selhurst Park | Premier League | |
| 12 Oct 2022 | Rangers | 7-1 | Ibrox Stadium | Champions L. 1st Group Ph. | |
| 23 Mar 1991 | Derby County | 7-1 | Baseball Ground | 1st Division | |
| 09 Feb 2002 | Ipswich Town | 6-0 | Portman Road | Premier League | |
| 26 Apr 2003 | West Bromwich Albion | 6-0 | The Hawthorns | Premier League | |
| 28 Sep 1968 | Wolves | 6-0 | Molineux | 1st Division | |
| 28 Oct 1981 | Exeter City | 6-0 | St James' Park | League Cup 2nd round 2L | |
| 14 Feb 2016 | Aston Villa | 6-0 | Villa Park | Premier League | |
| 27 Apr 2013 | Newcastle United | 6-0 | St James' Park | Premier League | |
| 24 Sep 2020 | Lincoln City | 7-2 | Sincil Bank | League Cup 3rd round | |
| 17 Apr 2023 | Leeds United | 6-1 | Elland Road | Premier League | |
| 02 Dec 2015 | Southampton | 6-1 | St Mary's | League Cup 5th round | |
| 05 Oct 1946 | Grimsby Town | 6-1 | Blundell Park | 1st Division | |
| 05 May 1990 | Coventry City | 6-1 | Highfield Road | 1st Division | |
| 20 Aug 1994 | Crystal Palace | 6-1 | Selhurst Park | Premier League | |
| 22 Aug 1993 | Swindon Town | 5-0 | County Ground | Premier League | |
| 10 Mar 1956 | Barnsley | 5-0 | Oakwell | 2nd Division | |
| 08 Aug 2001 | Haka | 5-0 | Olympia Stadion | Champions L. 3rd QR. 1st L | |
| 10 Apr 1982 | Manchester City | 5-0 | Maine Road | 1st Division | |
| 06 Nov 1982 | Everton | 5-0 | Goodison Park | 1st Division | |
| 23 Mar 1985 | West Bromwich Albion | 5-0 | The Hawthorns | 1st Division | |
| 28 Sep 1976 | Crusaders | 5-0 | Seaview | European Cup 1st R 2nd L | |
| 17 Aug 1964 | Knattspyrnufélag Reykjavíkur | 5-0 | Laugardalsvöllur | European Cup Pre-R. 1st L | |
| 15 Dec 2013 | Tottenham Hotspur | 5-0 | White Hart Lane | Premier League | |
| 14 Feb 2018 | Porto | 5-0 | Estadio da Dragao | CL 1st knockout r. 1st leg | |
| 23 Aug 2016 | Burton Albion | 5-0 | Pirelli Stadium | League Cup 2nd round | |
| 16 Oct 2021 | Watford | 5-0 | Vicarage Road | Premier League | |
| 24 Oct 2021 | Manchester United | 5-0 | Old Trafford | Premier League | |
| 03 Nov 2020 | Atalanta B.C. | 5-0 | Stadio di Bergamo | Champions L. 1st Group Ph. | |
| 29 Dec 2024 | West Ham United | 5-0 | London Stadium | Premier League | |
| 26 Dec 2004 | West Bromwich Albion | 5-0 | The Hawthorns | Premier League | |
| 04 Jan 1896 | Rotherham Town | 5-0 | Clifton Lane | 2nd Division | |
| 28 Oct 1893 | Arsenal | 5-0 | Manor Ground | 2nd Division | |
| 28 Dec 1893 | Crewe Alexandra | 5-0 | Nantwich Road | 2nd Division | |
| 22 Oct 1892 | Higher Walton | 5-0 | Moon's Mill | Lancashire League | |
| 12 Jan 1935 | Yeovil Town | 6-2 | Huish Park | FA Cup 3rd round | |
| 28 Apr 1906 | Corinthians | 5-1 | Craven Cottage | Sheriff of London Charity Shield | |
| 11 Nov 1905 | Middlesbrough | 5-1 | Ayresome Park | 1st Division | |
| 07 Mar 2024 | Sparta Prague | 5-1 | Letná Stadium | Europa League of 16 | |
| 22 Oct 2025 | Eintracht Frankfurt | 5-1 | Waldstadion | Champions L - League Ph. | |
| 28 Sep 2021 | Porto | 5-1 | Estadio da Dragao | Champions L. 1st Group Ph. | |
| 02 Dec 2017 | Brighton & Hove Albion | 5-1 | AMEX Stadium | Premier League | |
| 28 Dec 2008 | Newcastle United | 5-1 | St James' Park | Premier League | |
| 05 Dec 1964 | Burnley | 5-1 | Turf Moor | 1st Division | |
| 06 Sep 1965 | West Ham United | 5-1 | Upton Park | 1st Division | |
| 19 Apr 1930 | Sunderland | 0-6 | Anfield | 1st Division | |
| 26 Oct 1929 | Manchester City | 1-6 | Anfield | 1st Division | |
| 26 Mar 1937 | Manchester City | 0-5 | Anfield | 1st Division | |
| 03 Oct 1914 | Everton | 0-5 | Anfield | 1st Division | |
| 14 Dec 1907 | Newcastle United | 1-5 | Anfield | 1st Division | |
| 02 Mar 1898 | Derby County | 1-5 | Anfield | FA Cup 3rd round replay | |
| 07 Dec 1946 | Wolves | 1-5 | Anfield | 1st Division | |
| 15 Nov 1952 | Arsenal | 1-5 | Anfield | 1st Division | |
| 05 Sep 1953 | Preston North End | 1-5 | Anfield | 1st Division | |
| 19 Dec 1959 | Cardiff City | 0-4 | Anfield | 2nd Division | |
| 19 Sep 1964 | Everton | 0-4 | Anfield | 1st Division | |
| 05 Feb 1898 | Sheffield United | 0-4 | Anfield | 1st Division | |
| 28 Nov 1914 | Aston Villa | 3-6 | Anfield | 1st Division | |
| 09 Jan 2007 | Arsenal | 3-6 | Anfield | League Cup 5th round | |
| 21 Feb 2023 | Real Madrid | 2-5 | Anfield | CL 1st knockout r. 1st leg | |
| 20 Apr 1895 | Preston North End | 2-5 | Anfield | 1st Division | |
| 27 Oct 1951 | West Bromwich Albion | 2-5 | Anfield | 1st Division | |
| 12 Apr 1913 | Sunderland | 2-5 | Anfield | 1st Division | |
| 21 Jan 1928 | Sunderland | 2-5 | Anfield | 1st Division | |
| 13 Sep 1930 | Huddersfield Town | 1-4 | Anfield | 1st Division | |
| 31 Mar 1951 | Huddersfield Town | 1-4 | Anfield | 1st Division | |
| 16 Dec 1950 | Wolves | 1-4 | Anfield | 1st Division | |
| 13 Dec 1969 | Manchester United | 1-4 | Anfield | 1st Division | |
| 25 Sep 1909 | Sunderland | 1-4 | Anfield | 1st Division | |
| 25 Dec 1907 | Chelsea | 1-4 | Anfield | 1st Division | |
| 26 Nov 2025 | PSV Eindhoven | 1-4 | Anfield | Champions L - League Ph. | |
| 07 Feb 2021 | Manchester City | 1-4 | Anfield | Premier League | |
| 02 Oct 2005 | Chelsea | 1-4 | Anfield | Premier League | |
| 22 Oct 2014 | Real Madrid | 0-3 | Anfield | Champions L. 1st Group Ph. | |
| 29 Aug 2015 | West Ham United | 0-3 | Anfield | Premier League | |
| 29 Oct 2025 | Crystal Palace | 0-3 | Anfield | League Cup 4th round | |
| 11 Apr 2024 | Atalanta B.C. | 0-3 | Anfield | Europa League QF | |
| 22 Nov 2025 | Nottingham Forest | 0-3 | Anfield | Premier League | |
| 03 Nov 1894 | Burnley | 0-3 | Anfield | 1st Division | |
| 15 Oct 1898 | Aston Villa | 0-3 | Anfield | 1st Division | |
| 17 Feb 1934 | Bolton Wanderers | 0-3 | Anfield | FA Cup 5th round | |
| 06 Apr 1965 | West Bromwich Albion | 0-3 | Anfield | 1st Division | |
| 28 Mar 1932 | Huddersfield Town | 0-3 | Anfield | 1st Division | |
| 08 Feb 1936 | Sunderland | 0-3 | Anfield | 1st Division | |
| 18 Jan 1947 | Bolton Wanderers | 0-3 | Anfield | 1st Division | |
| 31 Jan 1948 | Portsmouth | 0-3 | Anfield | 1st Division | |
| 24 Aug 1955 | Sheffield Wednesday | 0-3 | Anfield | 2nd Division | |
| 02 Jan 1926 | Leicester City | 0-3 | Anfield | 1st Division | |
| 04 Feb 1939 | Everton | 0-3 | Anfield | 1st Division | |
| 25 Oct 1913 | Oldham Athletic | 0-3 | Anfield | 1st Division | |
| 07 Sep 1929 | Everton | 0-3 | Anfield | 1st Division | |
| 09 Mar 1929 | Arsenal | 2-4 | Anfield | 1st Division | |
| 30 Aug 1924 | Aston Villa | 2-4 | Anfield | 1st Division | |
| 02 Oct 1926 | Leeds United | 2-4 | Anfield | 1st Division | |
| 05 Mar 1955 | Stoke City | 2-4 | Anfield | 2nd Division | |
| 11 Dec 1954 | Birmingham City | 1-9 | St Andrews | 2nd Division | |
| 10 Nov 1934 | Huddersfield Town | 0-8 | Leeds Road | 1st Division | |
| 01 Jan 1934 | Newcastle United | 2-9 | St James' Park | 1st Division | |
| 01 Sep 1934 | Arsenal | 1-8 | Highbury | 1st Division | |
| 07 May 1932 | Bolton Wanderers | 1-8 | Burnden Park | 1st Division | |
| 01 Sep 1930 | West Ham United | 0-7 | Upton Park | 1st Division | |
| 07 Dec 1912 | Sunderland | 0-7 | Roker Park | 1st Division | |
| 11 Sep 1935 | Manchester City | 0-6 | Maine Road | 1st Division | |
| 28 Nov 1931 | Arsenal | 0-6 | Highbury | 1st Division | |
| 26 Sep 1953 | Charlton Athletic | 0-6 | The Valley | 1st Division | |
| 15 Apr 1963 | Tottenham Hotspur | 2-7 | White Hart Lane | 1st Division | |
| 04 Oct 2020 | Aston Villa | 2-7 | Villa Park | Premier League | |
| 24 May 2015 | Stoke City | 1-6 | Britannia St. | Premier League | |
| 06 Feb 1897 | Stoke City | 1-6 | Victoria Ground | 1st Division | |
| 01 Feb 1936 | West Bromwich Albion | 1-6 | The Hawthorns | 1st Division | |
| 28 Aug 1937 | Chelsea | 1-6 | Stamford Bridge | 1st Division | |
| 05 May 1928 | Manchester United | 1-6 | Old Trafford | 1st Division | |
| 22 Oct 1910 | Newcastle United | 1-6 | St James' Park | 1st Division | |
| 16 Jan 1932 | Aston Villa | 1-6 | Villa Park | 1st Division | |
| 02 May 1955 | Rotherham United | 1-6 | Millmoor | 2nd Division | |
| 28 Dec 1957 | Cardiff City | 1-6 | Ninian Park | 2nd Division | |
| 04 Oct 1958 | Huddersfield Town | 0-5 | Leeds Road | 2nd Division | |
| 11 Sep 1946 | Manchester United | 0-5 | Maine Road | 1st Division | |
| 18 Mar 1933 | Leeds United | 0-5 | Elland Road | 1st Division | |
| 02 Dec 1911 | Aston Villa | 0-5 | Villa Park | 1st Division | |
| 11 Sep 1905 | Aston Villa | 0-5 | Villa Park | 1st Division | |
| 20 Feb 1909 | Arsenal | 0-5 | Manor Ground | 1st Division | |
| 09 Apr 1909 | Everton | 0-5 | Goodison Park | 1st Division | |
| 31 Aug 1929 | Middlesbrough | 0-5 | Ayresome Park | 1st Division | |
| 17 Jan 1925 | Manchester City | 0-5 | Maine Road | 1st Division | |
| 06 Feb 1937 | Birmingham City | 0-5 | St Andrews | 1st Division | |
| 15 Sep 1894 | West Bromwich Albion | 0-5 | Stoney Lane | 1st Division | |
| 27 Oct 1894 | Aston Villa | 0-5 | Perry Barr | 1st Division | |
| 05 Jan 1895 | Sheffield Wednesday | 0-5 | Olive Grove | 1st Division | |
| 29 Apr 1899 | Aston Villa | 0-5 | Villa Park | 1st Division | |
| 26 Jan 1946 | Bolton Wanderers | 0-5 | Burnden Park | FA Cup 4th round 1st leg | |
| 17 Dec 2019 | Aston Villa | 0-5 | Villa Park | League Cup 5th round | |
| 09 Sep 2017 | Manchester City | 0-5 | Etihad Stadium | Premier League | |
| 02 Sep 1936 | Portsmouth | 2-6 | Fratton Park | 1st Division | |
| 06 Sep 1913 | Blackburn Rovers | 2-6 | Ewood Park | 1st Division | |
| 03 Apr 1915 | Aston Villa | 2-6 | Villa Park | 1st Division | |
| 29 Aug 1932 | Sheffield United | 2-6 | Bramall Lane | 1st Division | |
| 06 Feb 1932 | Grimsby Town | 1-5 | Blundell Park | 1st Division | |
| 24 Mar 1934 | Leeds United | 1-5 | Elland Road | 1st Division | |
| 08 Apr 1950 | Newcastle United | 1-5 | St James' Park | 1st Division | |
| 15 Nov 1947 | Sunderland | 1-5 | Roker Park | 1st Division | |
| 28 Sep 1957 | Charlton Athletic | 1-5 | The Valley | 2nd Division | |
| 12 Dec 1953 | Portsmouth | 1-5 | Fratton Park | 1st Division | |
| 19 Dec 1953 | Manchester United | 1-5 | Old Trafford | 1st Division | |
| 19 Dec 1992 | Coventry City | 1-5 | Highfield Road | Premier League |
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